Basic information of ELAVL1 :
| Official Symbol of Gene | ELAVL1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1994 |
| Official Full Name | ELAV like RNA binding protein 1 |
| Also known as | HUR; Hua; MelG; ELAV1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000066044 MIM:603466; AllianceGenome:HGNC:3312 |
| Map Location | 19p13.2 |
Sample information of multiple sclerosis:
| Detected Sample | occipital lobe and medulla oblongata |
| Sample Detail | obtained at autopsy |
| Detected Method | immunohistochemistry |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Japanese |
| Sample Size | 3 RRMS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 32947653 |
| Year | 2020 |
| Title | Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | It was highly expressed in the border zone of MS plaques, but weakly expressed in the center of demyelinating plaques.In addition, HuR expression in microglia was significantly greater in the border area of MS plaques compared to that in the center area or normal myelin area. |
| Mechanism/Pathway | HuR stabilizes cystatin F expression in the border zone of MS plaques in demyelinating disorders. |
