Basic information of CX3CR1 :

Official Symbol of Gene	CX3CR1
Species	Homo sapiens
Entrez Gene ID	1524
Official Full Name	C-X3-C motif chemokine receptor 1
Also known as	V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000168329 MIM:601470; AllianceGenome:HGNC:2558
Map Location	3p22.2

Sample information of multiple sclerosis:

Detected Sample	PBMCs
Sample Detail	N/A
Detected Method	flow cytometric analyses
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	19 RRMS patients / 19 healthy individuals

Literature information of multiple sclerosis :

Pubmed ID	16144955
Year	2005
Title	Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	The data confirm that MS patients showed a reduced CX3CR1 protein expression compared with control individuals.
Mechanism/Pathway	The reduced frequency of CX3CR1 NK cells demonstrated in our study might imply the presence of a defective cytotoxic effector NK cell population in MS patients. NK cells appear to be essential in regulating the immune response and in the development of autoimmune processes.