Basic information of CD40 :

Official Symbol of Gene	CD40
Species	Homo sapiens
Entrez Gene ID	958
Official Full Name	CD40 molecule
Also known as	p50; Bp50; CDW40; TNFRSF5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919
Map Location	20q13.12

Sample information of multiple sclerosis:

Detected Sample	PBMCs
Sample Detail	N/A
Detected Method	flow cytometry
Disease	MS
Disease subtype	N/A
Population	Caucasian Spanish
Sample Size	24 MS patients / 86 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	26068105
Year	2015
Title	The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	Comparison of B lymphocyte expression of CD40 in MS patients failed to show a significant effect of genotype on surface CD40 expression levels in total B lymphocytes, nave B lymphocytes or classical memory B lymphocytes.However, comparison of cell surface CD40 expression on B-lymphocytes between healthy controls and MS patients showed that CD40 expression was significantly lower in MS patients compared to healthy controls in all CD19+ B-lymphocytes, as well as in the nave B lymphocytes, classical memory B-lymphocyte and IgM memory B lymphocyte subsets.A subset comparison of patients and unaffected controls homozygous for the rs1883832 C allele (CC) also demonstrated a significant decrease in CD40 expression on the total B—lymphocytes of MS patients compared to controls.
Mechanism/Pathway	N/A