Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Flow Cytometry |
| Disease | MS |
| Disease subtype | RRMS, PPMS |
| Population | Spanish |
| Sample Size | 101 MS / 37 HC |
Literature information of multiple sclerosis :
| Pubmed ID | 34912348 |
| Year | 2021 |
| Title | Anti-Human Herpesvirus 6 A/B Antibodies Titers Correlate With Multiple Sclerosis-Associated Retrovirus Envelope Expression |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | pHERV-W ENV/syncytin-1 protein expression levels were significantly higher in MS patients compared to HD.Relating to PP-MS patients, they showed significantly higher protein expression levels in monocytes and NK cells compared to HD.Moreover, these patients showed significantly higher pHERV-W ENV/syncytin-1 protein expression levels in monocytes compared to RR-MS patients. |
| Mechanism/Pathway | The HERV-W family, and its two main members (multiple sclerosis-associated retrovirus, MSRV, and ERVWE1), have been the most studied ones concerning MS. ERVWE1 envelope protein (env), called syncytin-1, is a fusogenic protein essential for placental syncytiotrophoblast formation.In relation to MS, proinflammatory and neurotoxic properties of pHERV-W ENV could lead to the development and progression of the disease. |
