Basic information of Slc1a3 :

Official Symbol of Gene	Slc1a3
Species	Mus musculus
Entrez Gene ID	20512
Official Full Name	solute carrier family 1 (glial high affinity glutamate transporter), member 3
Also known as	Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000005360 AllianceGenome:MGI:99917
Map Location	15 A1; 15 3.82 cM

Sample information of multiple sclerosis:

Detected Sample	corpus callosum
Sample Detail	N/A
Detected Method	Western blot analysis
Disease	cuprizone-induced demyelination
Disease subtype	N/A
Population	C57BL/6 male mice
Sample Size	130 cuprizone / 100 controls

Literature information of multiple sclerosis :

Pubmed ID	23711509
Year	2013
Title	Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	30% higher protein levels of GLAST in the demyelinated CC compared to controls.
Mechanism/Pathway	Excitotoxicity is associated with a wide range of acute neurological and chronic neurodegenerative disorders .In the adult central nervous system (CNS), glutamate uptake from the extracellular space is predominantly controlled by the astroglialtransporters, excitatory amino acid transporter 1 (EAAT1) and EAAT2, which are known in the rat brain as GLAST and glutamate transporter-I (GLT-I), respectively.Glutamate signaling also seems to be involved in the pathology and repair of demyelinating disorders such as multiple sclerosis (MS).