Basic information of IL1R1 :
| Official Symbol of Gene | IL1R1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3554 |
| Official Full Name | interleukin 1 receptor type 1 |
| Also known as | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1RT1; IL-1R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115594 MIM:147810; AllianceGenome:HGNC:5993 |
| Map Location | 2q11.2-q12.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 9 RRMS patients / 10 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 25458313 |
| Year | 2015 |
| Title | Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Normalized IL-1Ra protein levels were increased in MS patients compared to HC. |
| Mechanism/Pathway | Since IL-1β is an extremely potent pro-inflammatory molecule, its secretion and effector functions need to be tightly regulated. However, also outside the cell, IL-1β activity is tightly regulated. Like IL-1β, the IL-1 receptor antagonist (IL-1Ra) binds to the IL-1 receptor (IL-1R) resulting in competition for binding to this receptor. |
