Basic information of GRN :

Official Symbol of Gene	GRN
Species	Homo sapiens
Entrez Gene ID	2896
Official Full Name	granulin precursor
Also known as	GEP; GP88; PEPI; PGRN; CLN11; PCDGF
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000030582 MIM:138945; AllianceGenome:HGNC:4601
Map Location	17q21.31

Sample information of multiple sclerosis:

Detected Sample	CSF
Sample Detail	N/A
Detected Method	ELISA
Disease	MS
Disease subtype	RRMS, SPMS, PPMS
Population	Italian
Sample Size	55 MS patients / 35 subjects with non-inflammatory neurological diseases (NIND) / 7 individuals with other inflammatory neurological disease (OIND) / 8 controls (CON)

Literature information of multiple sclerosis :

Pubmed ID	19963041
Year	2010
Title	Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes

Results of multiple sclerosis :

Expression	No significance
Risk type	Disease risk
Result	No statistically significant differences were found in patients compared with either NIND, OIND or CON, even stratifying according to disease subtype or gender.
Mechanism/Pathway	Multiple sclerosis (MS) is considered predominantly an inflammatory autoimmune disease of the central nervous system (CNS), with myelin proteins supposed to act as autoantigens, starting with aberrant activation of specific populations of autoreactive T lymphocytes in the periphery, followed by T cell recruitment into the brain.In fact, despite the full length protein displays trophic properties, its proteolitically derived peptides (granulins) act as pro-inflammatory mediators.Other evidence can be found about increased levels of GRN mRNA in several inflammatory neurodegenerative disorders associated with microglial activation such as ALS and virally induced CNS inflammation.Neuronal death is the pathological correlate of disease progression in multiple sclerosis.