Basic information of IGHV4-34 :
| Official Symbol of Gene | IGHV4-34 |
| Species | Homo sapiens |
| Entrez Gene ID | 28395 |
| Official Full Name | immunoglobulin heavy variable 4-34 |
| Also known as | VH; IGHV434 |
| Gene Type | other |
| dbXrefs | Ensembl:ENSG00000211956 IMGT/GENE-DB:IGHV4-34; AllianceGenome:HGNC:5650 |
| Map Location | 14q32.33 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 12 MS patiets / 52 normals |
Literature information of multiple sclerosis :
| Pubmed ID | 15598986 |
| Year | 2004 |
| Title | B cell lymphoproliferative disorders and VH4-34 gene encoded antibodies |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | Diseases such as multiple sclerosis (MS) display no increase in VH4-34 Ig. |
| Mechanism/Pathway | The human immunoglobulin heavy chain gene VH4- 34 is known to encode autoantibodies.Mediated principally by autoimmune T cells, these diseases do not stimulate natural immunity and thus may not be associated with activating the first line of defense response. |
