Basic information of RFX5 :

Official Symbol of Gene	RFX5
Species	Homo sapiens
Entrez Gene ID	5993
Official Full Name	regulatory factor X5
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000143390 MIM:601863; AllianceGenome:HGNC:9986
Map Location	1q21.3

Sample information of multiple sclerosis:

Detected Sample	white matter (NAWM)
Sample Detail	MS affected postmortem brain tissue
Detected Method	immunohistochemical
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	4 MS patients / 4 patients without neurological complications

Literature information of multiple sclerosis :

Pubmed ID	11571785
Year	2001
Title	Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	RFX5 was expressed at a moderate level in microglial cells and astrocytes of normal control brain tissue.The phagocytic macrophages in the lesions were strongly positive for RFX5 expression.
Mechanism/Pathway	RFX is specific for and directly involved in the expression of MHC genes.