Basic information of CIITA :

Official Symbol of Gene	CIITA
Species	Homo sapiens
Entrez Gene ID	4261
Official Full Name	class II major histocompatibility complex transactivator
Also known as	C2TA; NLRA; MHC2TA; CIITAIV
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067
Map Location	16p13.13

Sample information of multiple sclerosis:

Detected Sample	white matter (NAWM)
Sample Detail	MS affected postmortem brain tissue
Detected Method	immunohistochemical
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	4 MS patients / 4 patients without neurological complications

Literature information of multiple sclerosis :

Pubmed ID	11571785
Year	2001
Title	Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	CIITA was also moderately expressed in microglial cells, but weakly in astrocytes, and not in endothelial cells of the blood vessel walls in brain tissue of normal control cases. The phagocytic macrophages in the lesions were moderately positive for CIITA expression .
Mechanism/Pathway	The coactivator CIITA is specific for and directly involved in the expression of MHC genes.