Basic information of IRF1 :

Official Symbol of Gene	IRF1
Species	Homo sapiens
Entrez Gene ID	3659
Official Full Name	interferon regulatory factor 1
Also known as	MAR; IRF-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000125347 MIM:147575; AllianceGenome:HGNC:6116
Map Location	5q31.1

Sample information of multiple sclerosis:

Detected Sample	white matter (NAWM)
Sample Detail	MS affected postmortem brain tissue
Detected Method	immunohistochemical
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	4 MS patients / 4 patients without neurological complications

Literature information of multiple sclerosis :

Pubmed ID	11571785
Year	2001
Title	Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	In microglial cells localized in normal control white matter, the IRF1 was expressed at weak to moderate levels.The IRF1 was moderately to strongly expressed in phagocytic macrophages in MS lesions .
Mechanism/Pathway	directly or indirectly regulate the expression of MHC class I and class II genes