Basic information of Slc1a2 :
| Official Symbol of Gene | Slc1a2 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 29482 |
| Official Full Name | solute carrier family 1 member 2 |
| Also known as | Glt; Eaat2; Glt-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000005479 AllianceGenome:RGD:3697 |
| Map Location | 3q32 |
Sample information of multiple sclerosis:
| Detected Sample | forebrain |
| Sample Detail | N/A |
| Detected Method | immunoblotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | female Lewis rats |
| Sample Size | 4 EAE /4 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 18572325 |
| Year | 2008 |
| Title | Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Densitometric analysis showed approximately 40% enhancement of protein in EAE rat forebrain relative to control animals in this early phase of disease. |
| Mechanism/Pathway | The beneficial effects of glutamate receptors antagonists are strongly suggestive of involvement of glutamatergic receptor-mediated excitotoxicity in the pathogenesis of the disease.The key role in limiting the glutamatergic activity occurs by regulation of the level of extracellular glutamate by GluTs. |
