Basic information of A2M :
| Official Symbol of Gene | A2M |
| Species | Homo sapiens |
| Entrez Gene ID | 2 |
| Official Full Name | alpha-2-macroglobulin |
| Also known as | A2MD; CPAMD5; FWP007; S863-7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | nephelometry |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 326 MS patients / 290 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11498265 |
| Year | 2001 |
| Title | No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis |
Results of multiple sclerosis :
| Expression | no difference |
| Risk type | Disease risk |
| Result | No difference was observed for the A2M levels between both groups. |
| Mechanism/Pathway | Several biological functions have been described for A2M.The structure of the protein suggests a function as protein inhibitor.Furthermore, A2M binds to cytokines and seems to inactivate at least some of themThe protein also enhances antigen-driven immune responses by capturing antigen for presentation. |
