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Basic information of ADIPOQ :

Official Symbol of Gene ADIPOQ
Species Homo sapiens
Entrez Gene ID 9370
Official Full Name adiponectin, C1Q and collagen domain containing
Also known as ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Gene Type protein coding
dbXrefs Ensembl:ENSG00000181092 MIM:605441; AllianceGenome:HGNC:13633
Map Location 3q27.3

Sample information of multiple sclerosis:

Detected Sample serum
Sample Detail N/A
Detected Method ELISA
Disease MS
Disease subtype RRMS
Population N/A
Sample Size 44 MS patients / 44 controls

Literature information of multiple sclerosis :

Pubmed ID 30219158
Year 2018
Title Gender-Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis

Results of multiple sclerosis :

Expression down-regulation
Risk type Disease risk
Result Adiponectin levels were significantly higher in healthy controls compared to patients.
Mechanism/Pathway MS is mainly considered a Th1-mediated inflammatory disease,although recent studies postulate a vital role for helper T cells-17 (Th17 cells) in the pathogenesis of the disease .Therefore, the pathogenesis of MS is influenced by factors that affect the deviation of nave CD4+ Th cells towards Th1 or Th17 cells.Among different factors, the effects of adipokines such as adiponectin and leptin on Th cell deviation have recently drawn much attention.