Basic information of MAP2 :

Official Symbol of Gene	MAP2
Species	Homo sapiens
Entrez Gene ID	4133
Official Full Name	microtubule associated protein 2
Also known as	MAP-2; MAP2A; MAP2B; MAP2C
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000078018 MIM:157130; AllianceGenome:HGNC:6839
Map Location	2q34

Sample information of multiple sclerosis:

Detected Sample	sections of the brains
Sample Detail	N/A
Detected Method	Immunocytochemistry
Disease	MS
Disease subtype	acute MS,chronic active MS,chronic silent MS
Population	N/A
Sample Size	10 MS brains / five normal controls

Literature information of multiple sclerosis :

Pubmed ID	10582615
Year	1999
Title	A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	By immunocytochemistry using a series of monoclonal antibodies specific for MAP-2+13, we determined that MAP-2+13 expression was up-regulated in all 31 lesions from 10 different MS brains. MAP-2+13 was expressed in regenerating oligodendrocytes associated with demyelinated lesions, with the highest counts found in regions of extensive remyelination.
Mechanism/Pathway	MAP-2 is a family of heat-stable microtubule-associated proteins developmentally expressed in the nervous system. MAP-2 reduces the concentration of tubulin required to form microtubules and is involved in regulating cytoskeletal dynamics, dendritic elongation, and neuronal plasticity.