Basic information of BCL2 :
| Official Symbol of Gene | BCL2 |
| Species | Homo sapiens (human) |
| Entrez Gene ID | 596 |
| Official Full Name | BCL2 apoptosis regulator |
| Also known as | Bcl-2; PPP1R50 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000171791 MIM:151430; AllianceGenome:HGNC:990 |
| Map Location | 18q21.33 |
Sample information of multiple sclerosis:
| Detected Sample | autopsy tissues |
| Sample Detail | N/A |
| Detected Method | Immunocytochemistry |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | N/A |
| Sample Size | 5 RRMS / 6 PPMS |
Literature information of multiple sclerosis :
| Pubmed ID | 9717185 |
| Year | 1998 |
| Title | Bcl-2 expressing T lymphocytes in multiple sclerosis lesions |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Phenotypic risk |
| Result | Bcl-2 is expressed by T lymphocytes in MS plaques.Patients with chronic progressive MS have a higher proportion of bcl-2 expressing T cells than patients with relapsing remitting disease.Highest numbers of bcl-2-positive T lymphocytes were found in remyelinating and demyelinated lesions, whereas active demyelinating lesions revealed lower numbers. |
| Mechanism/Pathway | Studies in animal models of MS suggest that apoptosis of T cells is the main factor terminating inflammation.The process of apoptosis itself is regulated by a range of pro- and anti-apoptotic proteins.The bcl-2 gene family is an important member of these proteins. |
