Basic information of HLA-G :
| Official Symbol of Gene | HLA-G |
| Species | Homo sapiens |
| Entrez Gene ID | 3135 |
| Official Full Name | major histocompatibility complex, class I, G |
| Also known as | MHC-G |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204632 MIM:142871; AllianceGenome:HGNC:4964 |
| Map Location | 6p22.1 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Isfahan |
| Sample Size | 200 MS / 200 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 29924453 |
| Year | 2018 |
| Title | HLA-G gene polymorphism and soluble HLA-G serum level in patients with multiple sclerosis |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | We did not detect significantly different serum level of sHLA-G between groups. |
| Mechanism/Pathway | Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disorder of central nervous system in young population. It has been suggested that major histocompatibility complex (MHC) on chromosome 6p21 is the strongest genome-wide MS susceptibility factor. HLA-G is a non-classical HLA class I with limited polymorphisms. |
