Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | interleukin 2 receptor subunit alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
Sample information of multiple sclerosis:
| Detected Sample | plasma |
| Sample Detail | N/A |
| Detected Method | Quantikine ELISA |
| Disease | MS |
| Disease subtype | RRMS,SPMS,PPMS |
| Population | N/A |
| Sample Size | 51 MS / 18 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 28511943 |
| Year | 2017 |
| Title | Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis |
Results of multiple sclerosis :
| Expression | No significance |
| Risk type | Disease risk |
| Result | No significant differences were seen in the sCD25 levels between MS patients or MS subtypes and HCs. |
| Mechanism/Pathway | The soluble form of CD25 (sCD25) may function as an antagonist for IL-2 .However, sCD25 may also facilitate T cell activation and increased T cell proliferation has been observed after addition of sCD25.By sCD25 binding of IL-2 the IL-2 promoted activation induced cell death (AICD) could be prevented as well as the negative feedback inhibition of IL-2 itself .Furthermore, an increase in sCD25 levels enhanced the severity of experimental autoimmune encephalomyelitis (EAE).This occurred in association with increased antigen-specific T-cell expression of IL-17A in the periphery and increased numbers of both interferon-gamma (IFNγ) and IL-17 producing CD4+ T cells in the CNS. |
