Basic information of Cnr1 :
| Official Symbol of Gene | Cnr1 |
| Species | Rattus norvegicus (Norway rat) |
| Entrez Gene ID | 25248 |
| Official Full Name | cannabinoid receptor 1 |
| Also known as | SKR6R |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000008223 AllianceGenome:RGD:2369 |
| Map Location | 5q21 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | lyophilized extracts |
| Detected Method | isotope dilution-liquid chromatography/mass spectrometry (LC-MS) |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Lewis rats |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 16242629 |
| Year | 2005 |
| Title | Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We recorded a marked reduction of both anandamide and 2-arachidonoylglycerol in motor related regions (striatum, midbrain) but also in other regions such as the brainstem, diencephalon, hippocampus, limbic forebrain, and cerebral cortex. |
| Mechanism/Pathway | a reduction of CB1 receptor binding and mRNA levels, mainly in the basal ganglia , and a region-dependent down-regulation of endocannabinoid transmission in EAE rats |
