Basic information of Tspo :
| Official Symbol of Gene | Tspo |
| Species | Mus musculus |
| Entrez Gene ID | 12257 |
| Official Full Name | translocator protein |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000041736 AllianceGenome:MGI:88222 |
| Map Location | 15 E1; 15 39.4 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain and spinal cord |
| Sample Detail | N/A |
| Detected Method | Immunohistochemistry |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | (n = 8 animals per group). |
Literature information of multiple sclerosis :
| Pubmed ID | 26925573 |
| Year | 2016 |
| Title | The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | This decrease in astrogliosis was also witnessed in the lessening of severity of EAE clinical scoring, indicating an in vivo functional role for TSPO in suppressing EAE. |
| Mechanism/Pathway | TSPOFlox/Flox/hGFAPcre mice showed highly down regulated TPSO expression, with minimal expression of TPSO in the central canal |
