Basic information of S1pr1 :

Official Symbol of Gene	S1pr1
Species	Mus musculus
Entrez Gene ID	13609
Official Full Name	sphingosine-1-phosphate receptor 1
Also known as	S1p; Edg1; Lpb1; S1p1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000045092 AllianceGenome:MGI:1096355
Map Location	3; 3 G1

Sample information of multiple sclerosis:

Detected Sample	cell
Sample Detail	N/A
Detected Method	Flow cytometric analysis
Disease	EAE
Disease subtype	N/A
Population	C57BL/6
Sample Size	n = 3–5 mice per group.

Literature information of multiple sclerosis :

Pubmed ID	24076635
Year	2013
Title	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Mutant mice harboring an S1pr1 gene encoding phosphorylation-deficient receptors (S1P1(S5A)) developed severe experimental autoimmune encephalomyelitis (EAE) due to autoimmunity mediated by interleukin 17 (IL-17)–producing helper T cells (TH17 cells) in the peripheral immune and nervous system
Mechanism/Pathway	S1P1 directly activated the Jak-STAT3 signal-transduction pathway via IL-6. Impaired S1P1 phosphorylation enhances TH17 polarization and exacerbates autoimmune neuroinflammation