Basic information of Ikbkb :
| Official Symbol of Gene | Ikbkb |
| Species | Mus musculus |
| Entrez Gene ID | 16150 |
| Official Full Name | nhibitor of kappaB kinase beta |
| Also known as | IKK2; IKK-2; IKK[b]; IKKbeta; IKK-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031537 AllianceGenome:MGI:1338071 |
| Map Location | 8; 8 A2 |
Sample information of multiple sclerosis:
| Detected Sample | brain and spinal cord |
| Sample Detail | N/A |
| Detected Method | Immunoblot analysis |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Nes-Cre transgenic mice |
| Sample Size | n=38 |
Literature information of multiple sclerosis :
| Pubmed ID | 16892069 |
| Year | 2006 |
| Title | Inhibition of transcription factor NF-jBinthe central nervous system ameliorates autoimmune encephalomyelitis in mice |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | CNS-restricted ablation of ‘upstream’ NF-jB activators NEMO or IKK2 but not IKK1 ameliorated disease pathology in a mouse model of multiple sclerosis |
| Mechanism/Pathway | CNS-restricted ablation |
