Basic information of BIRC5 :
| Official Symbol of Gene | BIRC5 |
| Species | Homo sapiens |
| Entrez Gene ID | 332 |
| Official Full Name | baculoviral IAP repeat containing 5 |
| Also known as | API4; EPR-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089685 MIM:603352; AllianceGenome:HGNC:593 |
| Map Location | 17q25.3 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | pbmc |
| Detected Method | WB,ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 50 RRMS patients,50 healthy age- and sexmatched individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 32599467 |
| Year | 2020 |
| Title | Dysregulation of microRNAs regulating survivin in CD4+ T cells in Multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The mRNA of survivin was 2-folds upregulated in the CD4+ T cells from MS patients in comparison to the healthy controls (P= 0.0053). Serum level of survivin was higher in patients than controls. There was statistically significant downregulation of miR-485 (P= 0.001) and miR-708 (P= 0.011) in CD4+ T cells of patients compared with controls. The miR-485 downregulation had statistically significant correlation with the mRNA expression and serum level of survivin. |
| Mechanism/Pathway | persistent inflammatory condition |
