Basic information of MIR146A :
| Official Symbol of Gene | MIR146A |
| Species | Homo sapiens |
| Entrez Gene ID | 406938 |
| Official Full Name | microRNA 146a |
| Also known as | MIRN146; MIRN146A; miR-146a; miRNA146A |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000283733 MIM:610566; miRBase:MI0000477; AllianceGenome:HGNC:31533 |
| Map Location | 5q33.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | serum samples |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | Australian |
| Sample Size | This study has followed a subgroup of169 relapse onset cases who had a classic FDE (that is those who had their first ever episode consistent with inflammatory CNS demyelination immediately prior to study entry) |
Literature information of multiple sclerosis :
| Pubmed ID | 29127522 |
| Year | 2017 |
| Title | Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | the genotype (GC+CC) of rs2910164 predicted relapse compared with the GG genotype (HR=2.09 (95% CI 1.42, 3.06), p=0.0001), as well as a near-significant (p=0.07) association with MS conversion risk |
| Mechanism/Pathway | relative excess risk due to interaction |
