Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis facto |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMCs |
| Detected Method | WB |
| Disease | MS |
| Disease subtype | RRMS,CIS |
| Population | American |
| Sample Size | 23MS,17controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21061396 |
| Year | 2010 |
| Title | Interferon-b Inhibits Toll-Like Receptor 9 Processing in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This finding represents a novel immunomodulatory mechanism of IFN-b: inhibition of TLR9 processing. This results in decreased activation of pDCs by viral pathogens and, thus, may affect the frequency of MS exacerbations. |
| Mechanism/Pathway | inhibition of TLR9 processing |
