Basic information of IFNA2 :
| Official Symbol of Gene | IFNA2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3440 |
| Official Full Name | interferon alpha 2 |
| Also known as | IFNA; IFNA2B; leIF A; IFN-alphaA; IFN-alpha-2 |
| Gene Type | N/A |
| dbXrefs | Ensembl:ENSG00000188379 MIM:147562; AllianceGenome:HGNC:5423 |
| Map Location | 9p21.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMCs |
| Detected Method | WB |
| Disease | MS |
| Disease subtype | RRMS,CIS |
| Population | American |
| Sample Size | 23MS,17controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21061396 |
| Year | 2010 |
| Title | Interferon-b Inhibits Toll-Like Receptor 9 Processing in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This finding represents a novel immunomodulatory mechanism of IFN-b: inhibition of TLR12 processing. This results in decreased activation of pDCs by viral pathogens and, thus, may affect the frequency of MS exacerbations. |
| Mechanism/Pathway | inhibition of TLR12 processing |
