Basic information of Mbp :
| Official Symbol of Gene | Mbp |
| Species | Mus musculus |
| Entrez Gene ID | 17196 |
| Official Full Name | myelin basic protein |
| Also known as | jve; mld; shi; Hmbpr; golli-mbp |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925 |
| Map Location | 18 E3; 18 55.84 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | T cell |
| Detected Method | Gel electrophoresis and immunoblotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL |
| Sample Size | 10 mice of each treated group |
Literature information of multiple sclerosis :
| Pubmed ID | 10424450 |
| Year | 1999 |
| Title | A novel antigen-toxin chimeric protein: myelin basic protein-pseudomonas exotoxin (MBP-PE 40) for treatment of experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | A chimeric protein such as MBP-PE40 presents a novel prototype of chimeric proteins, composed of antigen/peptide-toxin, that could prove to be an efficient and specific immunotherapeutic agent for autoimmune diseases in which a known antigen is involved |
| Mechanism/Pathway | cytotoxic to various anti-MBP T cells |
