Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | CD4 T cells |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n = 3 |
Literature information of multiple sclerosis :
| Pubmed ID | 35121767 |
| Year | 2022 |
| Title | Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | high zinc aspartate concentrations was signifcantly impaired indicated by reduced expression of the T1 transcription factor Tbet and the T1 signature cytokine IFN-γ as well as of the cytokines IL-2 and TNF-αT1 cells and transferring them into C57BL/6 recipient mice. |
| Mechanism/Pathway | pro-inflammatory cytokines |
