Basic information of Atp2b2 :
| Official Symbol of Gene | Atp2b2 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 24215 |
| Official Full Name | ATPase plasma membrane Ca2+ transporting 2 |
| Also known as | PMCA2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000030269 AllianceGenome:RGD:2176 |
| Map Location | 4q42 |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | 2-3 lumbar spinal cords |
| Detected Method | IFHC;WB |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Lewis rats |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 12538406 |
| Year | 2003 |
| Title | Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Transcript and protein levels of plasma membrane Ca2+ ATPase 2 (PMCA2) were dramatically decreased coincident with the onset of clinical symp- toms |
| Mechanism/Pathway |
perturbations in Ca2+ balance and neurotransmitter exocytosis may partially underlie aberrant neuronal function and communication at onset of symptoms. Altered mitochondrial function and impulse conduction may exacerbate neurological de |
