Basic information of CIITA :

Official Symbol of Gene	CIITA
Species	Rattus norvegicus
Entrez Gene ID	85483
Official Full Name	class II, major histocompatibility complex, transactivator
Also known as	C2ta; Mhc2ta
Gene Type	protein coding
dbXrefs	Ensembl:ENSRNOG00000002659 AllianceGenome:RGD:619813
Map Location	10q11

Sample information of multiple sclerosis:

Detected Sample	CNS tissue
Sample Detail	N/A
Detected Method	N/A
Disease	EAE
Disease subtype	N/A
Population	DA rats
Sample Size	n = 4-6 per diet group

Literature information of multiple sclerosis :

Pubmed ID	33304315
Year	2020
Title	Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA ( Mhc2ta)

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	we could observe reduced protein expression of MHC class II and CIITA in the CNS of the congenic rats fed with vitamin D supplemented diet.
Mechanism/Pathway	CIITA (Mhc2ta) gene encodes class II transactivator, shown to be essential for MHC class II transcription and expression