Basic information of IL23A :
| Official Symbol of Gene | IL23A |
| Species | Homo sapiens |
| Entrez Gene ID | 15488 |
| Official Full Name | interleukin 23 subunit alpha |
| Also known as | P19; SGRF; IL-23; IL-23A; IL23P19 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000110944 MIM:605580; AllianceGenome:HGNC:15488 |
| Map Location | 12q13.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Elisa |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 30 MS cases and 30controls |
Literature information of multiple sclerosis :
| Pubmed ID | 16751425 |
| Year | 2006 |
| Title | IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | IL-23 expression is eleveted in monocyte-derived DCs from MS patients both at the protein and mRNA levels |
| Mechanism/Pathway | Our results demonstrate that an abnormal Th1 bias in DCs from MS patients related to IL-23 exists, and that antisense oligonucleotides specific to IL-23 can be used for immune modulation by targeting DC gene expression |
