Basic information of IL1RN :
| Official Symbol of Gene | IL1RN |
| Species | Homo sapiens |
| Entrez Gene ID | 6000 |
| Official Full Name | interleukin 1 receptor antagonist |
| Also known as | DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136689 MIM:147679; AllianceGenome:HGNC:6000 |
| Map Location | 2q14.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMSã€PPMS |
| Population | Dutch ancestry and Caucasian |
| Sample Size | 75 MS cases (50 RRMSã€25 PPMS) and 138 controls(54 spouses and 84 first-degree) |
Literature information of multiple sclerosis :
| Pubmed ID | 12020968 |
| Year | 2002 |
| Title | Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | we show that families that are characterized by high IL-1beta over IL-1Ra production ratio are at 2.2-fold (95% CI, 1.0-4.8; p=0.05) increased risk to have a patient relative with relapse-onset MS than families with a low ratio |
| Mechanism/Pathway | These studies indicate thatthe balance between IL-1hand IL-1Ra production mightbe of importance for MS, rather than the absolute level ofeach cytokine alone |
