Basic information of BDNF :
| Official Symbol of Gene | BDNF |
| Species | Homo sapiens |
| Entrez Gene ID | 1033 |
| Official Full Name | brain derived neurotrophic factor |
| Also known as | ANON2; BULN2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033 |
| Map Location | 11p14.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Elisa |
| Disease | MS |
| Disease subtype | CISã€RRMSã€SPMS |
| Population | N/A |
| Sample Size | 30 CIS patientsã€30 RRMS patients in relapseã€30 RRMS patients in remissionã€30 SPMS and 30 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36754216 |
| Year | 2023 |
| Title | Diagnostic and prognostic value of the RUNXOR/RUNX1 axis in multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | the protein levels of RUNX1, MAP2, NGF, BDNF and IL-10 were significantly decreased in MS patients compared to healthy controls |
| Mechanism/Pathway | Altogether, this study suggests the implication of the RUNXOR–RUNX1 axis in MS development, progression, and increased MS-related disability |
