Basic information of Nfe2l2 :
| Official Symbol of Gene | Nfe2l2 |
| Species | Mus musculus |
| Entrez Gene ID | 108420 |
| Official Full Name | nuclear factor, erythroid derived 2, like 2 |
| Also known as | Nrf2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420 |
| Map Location | 2 C3; 2 44.75 cM |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | Western Blotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 7 (case mice group)n = 7 (control mice group) |
Literature information of multiple sclerosis :
| Pubmed ID | 21354971 |
| Year | 2011 |
| Title | Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The relevance of our findings isunderlined by studies on multiple sclerosis autopsy tissue showingthat neuronal Nrf2 is also activated during the natural course ofmultiple sclerosis, similar to our findings in untreated EAE |
| Mechanism/Pathway | Nrf2-mediated neuroprotection may not only be directly mediated,but critically involves effects via astrocytes |
