Basic information of Ccr2 :
| Official Symbol of Gene | Ccr2 |
| Species | Homo sapiens |
| Entrez Gene ID | 12772 |
| Official Full Name | chemokine (C-C motif) receptor 2 |
| Also known as | Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000049103 AllianceGenome:MGI:106185 |
| Map Location | 9 F4; 9 75.05 cM |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | NA |
| Detected Method | real-time PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 19531531 |
| Year | 2009 |
| Title | CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Selective depletion of this specific monocyte subpopulation through engagement of CCR2 strongly reduced central nervous system autoimmunity. |
| Mechanism/Pathway | Collectively, these data indicate a disease-promoting role of CCR2+Ly-6Chi monocytes during autoimmune inflammation of the central nervous system. |
