Basic information of Rorc :
| Official Symbol of Gene | Rorc |
| Species | Mus musculus |
| Entrez Gene ID | 19885 |
| Official Full Name | RAR-related orphan receptor gamma |
| Also known as | TOR; Thor; Nr1f3; RORgamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028150 AllianceGenome:MGI:104856 |
| Map Location | 3; 3 F2.1 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | NA |
| Population | C57BL/8 |
| Sample Size | n=9 sample |
Literature information of multiple sclerosis :
| Pubmed ID | 25362566 |
| Year | 2013 |
| Title | MicroRNA-134 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Brain tissues from EAE mice showed significantly higher expression of RORct (p \ 0.01, Fig. 2a), IL17 (p \ 0.01, Fig. 2a), and IL6 (p \ 0.01, Fig. 2a) mRNA in the acute phase, but significantly lower expression of miR26a (p \ 0.01, Fig. 2b) and Foxp3 (p \ 0.05, Fig. 2a). |
| Mechanism/Pathway | As shown in Fig. 4 c through d, IL6 knockdown led to the downregulation of RORct (p \ 0.05, Fig. 4c), IL17 (Fig. 4c, p \ 0.05, and d, p \ 0.01), and IL6 (p \ 0.01, Fig. 4c, d) and to the upregulation of Foxp3 (p \ 0.05, Fig. 4c), results that were similar to those found by using miR28a. |
