Basic information of Fadd :
| Official Symbol of Gene | Fadd |
| Species | Mus musculus |
| Entrez Gene ID | 14082 |
| Official Full Name | Fas (TNFRSF6)-associated via death domain |
| Also known as | Mort1/FADD |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031077 AllianceGenome:MGI:109324 |
| Map Location | 7 F5; 7 88.85 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA，western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 12574377 |
| Year | 2015 |
| Title | Expression of the Long Form of Human FLIP by Retroviral Gene Transfer of Hemopoietic Stem Cells Exacerbates Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | We found that overexpression of the long form of human FLICE-inhibitory protein by retroviral gene transfer of hemopoietic stem cells led to a clinically more severe EAE in these mice compared with control mice receiving the retroviral vector alone. |
| Mechanism/Pathway | Subsidence of inflammation and clinical recovery in experimental autoimmune encephalomyelitis (EAE) is postulated to involve apoptosis of inflammatory cells. |
