Basic information of STAT1 :
| Official Symbol of Gene | STAT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6772 |
| Official Full Name | signal transducer and activator of transcription 1 |
| Also known as | CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115415 MIM:600555; AllianceGenome:HGNC:11362 |
| Map Location | 2q32.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | NA |
| Sample Size | 6MS |
Literature information of multiple sclerosis :
| Pubmed ID | 24586361 |
| Year | 2014 |
| Title | Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Treatment risk |
| Result | Based on this proof of concept study, we hypothesize that NAb effects can be monitored by evaluation of a single biomarker, pStat1, in either monocytes or T cells by phosphoflow directly after IFN-b administration. The method will significantly reduce cost relative to labor intensive in vitro methods and offers a patient-specific approach to NAb evaluation. |
| Mechanism/Pathway | Anti interferon-beta (IFN-b) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. Quantification of intracellular pathway-specific phosphorylation by phospho-specific flow cytometry (phosphoflow) is a promising tool for evaluation of these effects in primary immune cells from treated patients at the single-cell level. |
