Basic information of CXCR4 :
| Official Symbol of Gene | CXCR4 |
| Species | Homo sapiens |
| Entrez Gene ID | 7852 |
| Official Full Name | C-X-C motif chemokine receptor 4 |
| Also known as | FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121966 MIM:162643; AllianceGenome:HGNC:2561 |
| Map Location | 2q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 22MS/25Health |
Literature information of multiple sclerosis :
| Pubmed ID | 31421626 |
| Year | 2019 |
| Title | Circulating mesenchymal stem cells, stromal derived factor (SDF)-1 and IP-10 levels increased in clinically active multiple sclerosis patients but not in clinically stable patients treated with beta interfero |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Circulating MSCs, IP-10 and SDF-1α levels, increased in RRMS patients with clinically active not on DMT and IFN-β therapy reduced circulating MSCs and SDF-1α levels. |
| Mechanism/Pathway | Mesenchymal stem cells (MSCs) have the capacity to migrate into the inflammatory regions in response to chemokines such as, IP-10 and SDF-1α and function as anti-inflammatory and immunomodulatory cells |
