Basic information of MAPT :
| Official Symbol of Gene | MAPT |
| Species | Homo sapiens |
| Entrez Gene ID | 4137 |
| Official Full Name | microtubule associated protein tau |
| Also known as | TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000186868 MIM:157140; AllianceGenome:HGNC:6893 |
| Map Location | 17q21.31 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | NA |
| Detected Method | Immunoprecipitation |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 36221144 |
| Year | 2022 |
| Title | Tau seeding in cases of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Immuno-histochemistry with AT8 and MD3.1 confirmed prior reports of tau accumulation in MS. Although larger studies are required, our data suggest that progressive MS may be considered a secondary tauopathy |
| Mechanism/Pathway | Relapsing remitting multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system that in many cases leads to progressive MS, a neurodegenerative disease. |
