Basic information of SGPL1 :
| Official Symbol of Gene | SGPL1 |
| Species | Homo sapiens |
| Entrez Gene ID | 8879 |
| Official Full Name | sphingosine-1-phosphate lyase 1 |
| Also known as | SPL; S1PL; NPHS14 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000166224 MIM:603729; AllianceGenome:HGNC:10817 |
| Map Location | 10q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | Immunoprecipitation，Western blot |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 803 cases and 1516 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26433934 |
| Year | 2015 |
| Title | A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Treatment risk |
| Result | Among the exclusive binding partners of the risk variant, we describe the novel interaction with sphingosine 1-phosphate lyase (SGPL1)—a key enzyme for the creation of the sphingosine-1 phosphate gradient, which is relevant to the pathogenic process and therapeutic management of MS. |
| Mechanism/Pathway | Despite recent progress in the characterization of genetic loci associated with multiple sclerosis (MS) risk, the ubiquitous linkage disequilibrium operating across the genome has stalled efforts to distinguish causative variants from proxy single-nucleotide polymorphisms (SNPs). |
