Basic information of IL6ST :
| Official Symbol of Gene | IL6ST |
| Species | Homo sapiens |
| Entrez Gene ID | 3572 |
| Official Full Name | interleukin 6 cytokine family signal transducer |
| Also known as | CD130; GP130; HIES4; IMD94; STWS2; CDW130; HIES4A; HIES4B; IL-6RB; sGP130 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134352 MIM:600694; AllianceGenome:HGNC:6021 |
| Map Location | 5q11.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS |
| Population | Swedish |
| Sample Size | 104MS |
Literature information of multiple sclerosis :
| Pubmed ID | 28941836 |
| Year | 2017 |
| Title | Multiple sclerosis treatment effects on plasma cytokine receptor levels |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Treatment risk |
| Result | During natalizumab treatment we observed a decline in sgp130 and sIL-7Rα levels, while subsequent fingolimod treatment lead to increased sgp130 and sIL-7Rα and decreased sIL-2Rα levels. |
| Mechanism/Pathway | Genetic variants within some cytokine receptor genes have been associated with MS susceptibility, including IL7RA and IL2RA. |
