Basic information of MMP3 :
| Official Symbol of Gene | MMP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 4314 |
| Official Full Name | matrix metallopeptidase 3 |
| Also known as | SL-1; STMY; STR1; CHDS6; MMP-3; STMY1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000149968 MIM:185250; AllianceGenome:HGNC:7173 |
| Map Location | 11q22.2 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | B cell |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 6 cases and 15 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36389698 |
| Year | 2022 |
| Title | Identification of a novel role for matrix metalloproteinase-3 in the modulation of B cell responses in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Autopsied brain sections from multiple sclerosis patients containing aggregates of B cells expressed a significantly higher amount of matrix metalloproteinase-3 compared to controls |
| Mechanism/Pathway | There has been a growing interest in the presence and role of B cell aggregates within the central nervous system of multiple sclerosis patients. |
