Basic information of HSPA4 :
| Official Symbol of Gene | HSPA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3308 |
| Official Full Name | eat shock protein family A (Hsp70) member 4 |
| Also known as | RY; APG-2; HSPH2; hsp70; hsp70RY; HEL-S-5a; HS24/P52 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000170606 MIM:601113; AllianceGenome:HGNC:5237 |
| Map Location | 5q31.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | NA |
| Detected Method | ELISA，western blot |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 549 cases and 540controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20806409 |
| Year | 2010 |
| Title | Aberrant Stress-Induced Hsp70 Expression in Immune Cells in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These results indicate that immune cells from MS patients are more prone to Hsp70 induction under stress conditions, suggesting a possible link between Hsp70 overexpression and development of auto-immunity. |
| Mechanism/Pathway | Heat shock protein 70 (Hsp70), a prominent member of the heat shock protein family, is a stress-induced chap-erone, contributing to the ‘‘protein triage’’ mechanism |
