Basic information of TREM2 :
| Official Symbol of Gene | TREM2 |
| Species | Homo sapiens |
| Entrez Gene ID | 54209 |
| Official Full Name | triggering receptor expressed on myeloid cells 2 |
| Also known as | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000095970 MIM:605086; AllianceGenome:HGNC:17761 |
| Map Location | 6p21.1 |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS |
| Population | N/A |
| Sample Size | RRMS (N = 36)，SPMS(N = 20)，PPMS(N = 3)，and Control(N = 27)。 |
Literature information of multiple sclerosis :
| Pubmed ID | 26754805 |
| Year | 2016 |
| Title | Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Increased CSF levels of sTREM-2, a new marker of microglial activation, in MS and nor-malization upon treatment with either natalizumab or mitoxantrone support a role for microglial activa-tion in active MS. |
| Mechanism/Pathway | Microglia-mediated proteolysis of the triggering receptor expressed on myeloid cells-2 (TREM-2) produces soluble TREM-2 (sTREM-2) that can be measured in cerebrospinal fluid (CSF) samples. |
