Basic information of TNFRSF11B :
| Official Symbol of Gene | TNFRSF11B |
| Species | Homo sapiens |
| Entrez Gene ID | 4982 |
| Official Full Name | TNF receptor superfamily member 11b |
| Also known as | OPG; TR1; OCIF; PDB5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000164761 MIM:602643; AllianceGenome:HGNC:11909 |
| Map Location | 8q24.12 |
Sample information of multiple sclerosis:
| Detected Sample | PBL and CSF |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS/RRMS |
| Population | NA |
| Sample Size | 33MS/30RRMS/35Control |
Literature information of multiple sclerosis :
| Pubmed ID | 29920500 |
| Year | 2017 |
| Title | RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Our study revealed that changes of RANKL/RANK/OPG axis are associated with MS, particularly the decreased OPG level in the CSF at disease onset. Therefore, these factors may serve as disease bio-markers and molecular targets of novel therapeutic ap-proaches. |
| Mechanism/Pathway | Our study focused on the RANKL (receptor acti-vator of nuclear factor-κB ligand)/RANK/OPG (osteoprote-gerin) axis and selected proinflammatory/immunoregula-tory upstream mediators in the peripheral blood (PBL) and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients |
