Basic information of LEPR :
| Official Symbol of Gene | LEPR |
| Species | Homo sapiens |
| Entrez Gene ID | 3953 |
| Official Full Name | leptin receptor |
| Also known as | OBR; OB-R; CD295; LEP-R; LEPRD |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000116678 MIM:601007; AllianceGenome:HGNC:6554 |
| Map Location | 1p31.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS |
| Population | Iranian |
| Sample Size | 232MS/204Control |
Literature information of multiple sclerosis :
| Pubmed ID | 27105071 |
| Year | 2016 |
| Title | Polymorphism in Leptin and Leptin Receptor Genes May Modify Leptin Levels and Represent Risk Factors for Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our study implicates a significant role of LEP and LEPR polymorphisms and also leptin levels in the risk of MS and its severity. |
| Mechanism/Pathway | Leptin, the product of the ob gene, can modulate the immune responses and also seems to regulate Th1/Th2 balance by promoting a shift from the Th2 to the Th1 inflammatory cytokine pathway. |
