Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | Peripheral blood |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | N/A |
| Sample Size | 123 female and 43 male patients with MS |
Literature information of multiple sclerosis :
| Pubmed ID | 25173940 |
| Year | 2014 |
| Title | Tumor necrosis factor beta NcoI polymorphism is associated with inflammatory and metabolic markers in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Males carrying the TNFB2/B2 genotype exhibited increased levels of TNF-α, IFN-γ, and IL-17 (p = 0.0326) and decreased levels of IL-4, IL-10, insulin, and HOMA-IR. |
| Mechanism/Pathway | pro-inflammatory cytokines |
