Basic information of NEFL :
| Official Symbol of Gene | NEFL |
| Species | Homo sapiens |
| Entrez Gene ID | 4747 |
| Official Full Name | neurofilament light chain |
| Also known as | NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000277586 MIM:162280; AllianceGenome:HGNC:7739 |
| Map Location | 8p21.2 |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 211MS |
Literature information of multiple sclerosis :
| Pubmed ID | 32255388 |
| Year | 2019 |
| Title | Neurofilament levels are associated with blood–brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | sNfL levels during the first demyelinating event of MS are associated with greater impair-ment of BBB integrity, immune cell extravasation, and brain lesion activity on MRI. |
| Mechanism/Pathway | To investigate the associations of neurofilament light chain (NfL) levels with measures of BBB integrity and central nervous system (CNS) inflammation in MS during the first demyelinating event. |
