Basic information of IL12RB2 :
| Official Symbol of Gene | IL12RB2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3595 |
| Official Full Name | interleukin 12 receptor subunit beta 2 |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000081985 MIM:601642; AllianceGenome:HGNC:5972 |
| Map Location | 1p31.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 45MS |
Literature information of multiple sclerosis :
| Pubmed ID | 26439963 |
| Year | 2015 |
| Title | Higher expression of IL-12Rβ2 is associated with lower risk of relapse in relapsing–remitting multiple sclerosis patients on interferon-β1b therapy during 3-year follow-up |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Treatment risk |
| Result | Higher IL-12Rβ2 m R N A l e v e l s were associated with lower risk of relapse. Despite recent reports regarding role of GM-CSF in MS, our study failed to demonstrate its significance as therapy response biomarker, both on the mRNA and protein level. |
| Mechanism/Pathway | Cytokines produced by helper T (Th)1 cells, Th17 and regulatory T cells (Treg) are involved in multiple sclerosis (MS) immunopathogenesis. |
